When the exhibits at New York's Natural History Museum start behaving strangely, Larry Daley (Ben Stiller) -- now the director of nighttime operations -- must find out the cause. He learns that the Tablet, which magically brings Teddy Roosevelt (Robin Williams), Jedediah (Owen Wilson) and the other exhibits to life at night, has started to decay. Larry, along with his son and museum friends, must travel to London's British Museum to learn how to prevent the Tablet's magic from disappearing.

Yet another classic television series from the 1960s gets a big-screen update in this action-comedy inspired by the Bill Cosby/Robert Culp vehicle I Spy. Alex Scott (Owen Wilson) is a federal intelligence agent who has been assigned to find a particularly expensive and valuable weapon which has gone missing: a special stealth fighter jet which can not only hide from radar, but also turn invisible to the human eye. Scott learns a rogue agent has sold the jet to Gundars (Malcolm McDowell), a powerful and unscrupulous underground arms dealer. After blowing his opportunity to catch Gundars in the act, Scott formulates a Plan B -- it seems Gundars is a rabid boxing fan, so in order to get inside his organization, Scott recruits Kelly Robinson (Eddie Murphy), a longtime middleweight champion whose ego nearly exceeds his talent in the ring. Robinson is excited by the prospect of a life of espionage, but Scott and Robinson's personalities are like oil and water, and matters are hardly helped by the efforts of less-than-helpful fellow agents Rachel (Famke Janssen) and Carlos (Gary Cole). This adaptation of I Spy was directed by a woman who starred in a memorable television series herself, former Hill Street Blues regular Betty Thomas, who has gone on to a successful career behind the camera.