When the difficult star of the reality television show "Expedition Survival" disappears while filming an episode in the Florida Everglades using animals from the wildlife refuge run by Wahoo Crane's family, Wahoo and classmate Tuna Gordon set out to find him while avoiding Tuna's gun-happy father.

With love and determination befitting the "world's greatest family," twelve-year-old Deza Malone, her older brother Jimmie, and their parents endure tough times in Gary, Indiana, and later Flint, Michigan, during the Great Depression.

Ten-year-old Jane Doe, the only student average enough to be excluded from the town of Remarkable's School for the Remarkably Gifted, is joined at her public school by the trouble-making Grimlet twins, who lead her on a series of adventures involving an out-of-control science fair project, a pirate captain on the run from a mutinous crew, a lonely dentist, and a newly constructed bell tower that endangers Remarkable's most beloved inhabitant--a skittish lake monster named Lucky.