The story tells the investigation started by symbolist Robert Langdon and a good-looking cryptologist, Sophie Neveu, around the murder of a Museum Louvre's curator. In fact, the unfortunate murdered man was Sophie's grandfather, and the corpse was found with a series of symbols and codes, like a pentagram and a Fibonacci number sequence. But police detective Fache will begin to chase Langdon, who escapes after receiving a warning about the captain's real intentions. Sophie has with her a kind of key with dots and number 24 engraved on it, which opens to her and Langdon a big complex investigation that involves a supposedly heretic theory: Jesus Christ and Mary Magdalene were, in fact, a couple who produced a daughter named Sara. A millenarian sect called The Priory of Sion has kept for centuries the secret of that matter. A masochist and kind of psychopath albino monk, Sibilas, an Opus Dei member, will chase Langdon and Sophie as well, in order to impede that they solve the mystery of Christ and Mary Magdalene, and also the real meaning and location of the Holy Grail. A passionate British researcher, will help Langdon in his quest, revealing to them several symbolisms in Da Vinci's master work The Last Supper, traveling to mythical places in the UK, such as The Church Temple, where it is believed that a group of Templars Knights are buried, and Sir Isaac Newton's tomb at Westminster Abbey, where are located some of the main keys to solve the Holy Grail's mystery.

Former superhero Jack Shepard, (also known as Captain Zoom), is called back to work to transform an unlikely group of ragtag kids into a new generation of superheroes at a privacy Academy and save the world from certain destruction. The project holds an audition of would-be members, most of whom possess useless or disgusting powers. In the end, Dylan, a 17-year-old boy who can turn invisible Summer, a 16-year-old girl with telekinetic powers Tucker, a 12-year-old boy with the power to enlarge any part of his body Cindy, a 6-year-old girl with super strength.

As the film begins. A former criminal and drug dealer Lucky (Wesley Snipes) was released from prison and tries to lead a respectable life despite his troubled past. However, Lucky once or twice reflects on the wisdom of his grandfather who supposedly told him "sometimes without bad luck, it would seem you don't have any luck at all." Shortly after his release from prison, Lucky tries to get back on his feet but inexplicably ends up a victim of Hurricane Katrina's wrath, and loses his newly found life. After Lucky returns to New York, Lucky is dealt another blow when the government withdraws funds for his yoga and samba dance classes which he uses to try to keep kids off the streets. This unfortunate event leads to Lucky enduring the bad influences of two old friends from his past life as a criminal, who lure Lucky to a strip club under the false pretense of his friend's birthday. When a drug deal with some dangerous mobsters goes bad, and Lucky is now on the run with a feisty Puerto Rican stripper from the strip club, Angela (Jacquelyn Quinones), and over $500,000 in American currency, which is wired with marking dye. Later that night, there are short cuts of an unconventional and troubled couple, unexplained and also known to the police as the "Sawtooth Killers". Chang (James Liao), an egotistical and maniacal accomplice to his old-fashioned girlfriend Cass (Cybill Shepherd), the mother of a mentally challenged man named Eugene (Mike Messier). Motivated by Cass's son Eugene is unpleasant experiences with society's rejection of mentally challenged individuals, the couple brutally kidnaps, tortures, and presumably kills their abductees, recording their exploits on video, possibly for future viewing. Angela and Lucky find themselves caught up in the path of violence, and Lucky ends up an unlikely hero by saving the life of a would be victim of the Sawtooth Killers. However, Lucky saving Captain Davis (Mario Van Peebles), from Cass's son Eugene who is armed with a shovel. Lucky choosing to have a positive outlook on the events by using perspective gained from his grandfather, characterizes the events as being "the luckiest day in an unlucky man's life." Lucky and Angela go on to receive a $200,000 reward which had been offered by the police for information leading the capture, arrest, and or prosecution of the Sawtooth Killers.