Anand (Salman Khan) is patient no. 36 at Sir Richard's mental sanitorium. Dr. Tanvi (Kareena Kapoor) has been geven the reponsibility to restore Anand's sanity to make him fit enought to re-enter the real world. While treating him, Dr. Tanvi discovers the real story behind Anand's tragic past and the reason which led him to loose his sanity. Maya (Rimu Sen) was the woman who Anand dearly loved and cherished, her death in afreak accident on the eve of their wedding led to Anand's insane state. Dr. Tanvi is successful in bringing back Anand to normally but in this process falls in love with him.

Who doesn't love to have a hearty laugh given today's frantic lifestyles? The deadly trio, Baburao, Shyam and Raju (Paresh Rawal, Sunil Shetty and Akshay Kumar) are back in the sequel to HERA PHERI (2000), with comedy kings Johnny Lever, Rajpal Yadav, etc. and the delighful Bipasha Basu and Rimi Sen. The greedy trio, who tried to strike it rich in the last outing are now scouting for investment options. Raju spots an option that promises to double the investment. But it's beyond what they're saved.