The executive Beth Emhoff returns from a business trip to Hong Kong with a stop over at the Chicago airport, where she has sex with her former lover. Beth feels ill but she believes that the problem is jet leg. She travels back home to Minneapolis and spreads the virus to her son Clark and her husband Mitch. When Beth and Clark die, Mitch goes in quarantine where the doctors realize that he is immune to the mysterious virus. Meanwhile in Hong Kong, London and in a small province, people have the same disease. The American CDC and the World Health Organization give their best effort researching the virus that is spreading in a geometric progression. The outbreak is threatening the worldwide population of annihilation, unless a vaccine is well-succeeded. The scientists begin a fight against time.

The Back-up Plan is a comedy that explores dating, love, marriage and family in reverse. After years of dating, Zoe (Jennifer Lopez) has decided waiting for the right one is taking too long. Determined to become a mother, she commits to a plan, makes an appointment and decides to go it alone. That same day, Zoe meets Stan (Alex OLoughlin) a man with real possibilities. Trying to nurture a budding relationship and hide the early signs of pregnancy becomes a comedy of errors for Zoe and creates confusing signals for Stan. When Zoe nervously reveals the reason for her unpredictable behavior, Stan commits fully and says hes in. Never before has love seen a courtship where a wild night of sex involves three in a bed Stan, Zoe and the ever-present massive pregnancy pillow. Or, where date night consists of being the focal point at a near-strangers water birth which does for kiddie pools what Jaws did for swimming in the ocean. The real pregnancy test comes when both of them realize they really dont know each other outside of hormonal chaos and birth preparations. With the nine month clock ticking, both begin to experience cold feet. Anyone can fall in love, get married and have a baby but doing it backwards in hyper-drive could be proof positive that they were made for each other.