The executive Beth Emhoff returns from a business trip to Hong Kong with a stop over at the Chicago airport, where she has sex with her former lover. Beth feels ill but she believes that the problem is jet leg. She travels back home to Minneapolis and spreads the virus to her son Clark and her husband Mitch. When Beth and Clark die, Mitch goes in quarantine where the doctors realize that he is immune to the mysterious virus. Meanwhile in Hong Kong, London and in a small province, people have the same disease. The American CDC and the World Health Organization give their best effort researching the virus that is spreading in a geometric progression. The outbreak is threatening the worldwide population of annihilation, unless a vaccine is well-succeeded. The scientists begin a fight against time.

Something has gone wrong at aremote scientific research station on Mars. All research has creased. Communication has failed, and the messages that do get through are less then comforting. It's a level 5 quarantine and the only souls allowed in or out are the Rapid Response Tactical Squad, a squadron armed to the teeth with unprecedented firepower to carry on their mission nothing gets out alive. But a legion of nightmarish creatures of unknown origin lurks behind ever wall and stalks the countless rooms and tunnels.... far more powerful and blood-thirsty than anyone could ever imagine. Doom brings ou all the visceral exitement and starting action that made its game predecessor' a global phenomenon.