The PBS Nova film, in three-episodes of one hour each, was hosted by Kirk Johnson (Director of the Smithsonian National Museum of Natural History); Peter Oxley directed the first episode while Gwyn Williams directed the second and third. The series describes the very beginnings and later developments of the North American continent: from the origin of planet Earth 4.54 billion years ago; to the various movements of tectonic plates and their effect on the sculpturing of the continent's land and mountains, including the Rocky Mountains, Yellowstone and the Grand Canyon; to the emergence of life on the continent and its later evolution; and, finally, to the more recent settlement of the land by humans. According to Johnson, "Most people will not have considered a time when there was no North America ... What was there before North America? How did it form? When did it start? How did it come together?"

When the exhibits at New York's Natural History Museum start behaving strangely, Larry Daley (Ben Stiller) -- now the director of nighttime operations -- must find out the cause. He learns that the Tablet, which magically brings Teddy Roosevelt (Robin Williams), Jedediah (Owen Wilson) and the other exhibits to life at night, has started to decay. Larry, along with his son and museum friends, must travel to London's British Museum to learn how to prevent the Tablet's magic from disappearing.