In futuristic Satellite City, fourteen-year-old Cosmo Hill escapes from his abusive orphanage and teams up with three other people who share his unusual ability to see supernatural creatures, and together they determine the nature and purpose of the swarming blue Parasites that are invisible to most humans.

A Car collides with a wolf one snowy night on a lonely mountain road. The driver, Will Randall (Jack Nicholson) gets out to see if the wolf is badly hurt. The injured animal runs off and disappears into woods, but not before giving Will a deep bite on the wrist. From this moment, Will's life begins to change. The transformation is suble at first, as his senses become more acute and his perceptions of those around him sharpen. With each passing day, he is drawn deeper into the mystical feral spirit of the wolf. For Will Randall, nothing - not his job, not is marrieage, nor any part of his life - will ever be the same again.