Cherry has lost her leg in a roadside attack and now she, El Wray and a select few have to go up against the town folks who have turned into zombies after being infected by a virus.

When the evil wizard Gargamel (Hank Azaria) chases the Smurfs out of their village, they're forced through a portal, out of their world and into ours, landing in the middle of New York's Central Park. Just three apples high and stuck in the Big Apple, the Smurfs must find a way to get back to their village before Gargamel tracks them down.